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Conversely, histone acetylation by histone acetyltransferases (HATs) loosens chromatin, facilitating gene transcription [260]

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Ethics approval and consent to participate All procedures performed in studies involving human participants were in accordance with the Declaration of Helsinki, and the research protocols were approved by the Research Ethics Committee of China Medical University and the First Affiliated Hospital of China Medical University (ethical batch number: [2019] 2019-57-2)